EGFR and neoplasm: In this study, EGFR expression was found to be independent from tumor stage or initial nodal involvement; in multivariated analysis, it showed to be an independent pronostic factor of overall survival (P = 0.006), and of disease-free survival (P = 0.003), as well as a robust pronostic factor of locoregional relapse (P = 0.002) but not of distant relapse (P = 0.50).