TP53 and breast adenocarcinoma: WEB-2086 effects have been then analysed further in breast adenocarcinoma cells: MCF-7 which are hypotetraploid, ERα-positive and low-mobility cells expressing the wild-type p53 form; and MDA-MB-231 which are hypotriploid, ERα-negative and highly invasive cells carrying a mutated and inactive p53 form.