This in vitro profile translates into in vivo efficacy, where AMN107 has been shown to prolong the survival of mice injected with BCR-ABL-transformed haematopoietic cell lines or primary marrow cells, and to prolong survival in imatinib-resistant CML mouse models (Weisberg et al, 2005). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.