The presence of FGFR4 may facilitate the proliferative and angiogenic effects of bFGF and thus confer an increased metastatic potential to the melanoma cells (Rak and Kerbel, 1997; Wang and Becker, 1997; Compagni et al, 2000; Straume and Akslen, 2002). This evidence concerns the gene FGF2 and melanoma.