One of the best characterised activators for cell growth, proliferation, differentiation and migration in melanoma is basic fibroblast growth factor (bFGF) (Klagsbrun and Baird, 1991; Bikfalvi et al, 1997), a multifunctional cytokine that interacts with four different types of high-affinity receptors (FGFR1-4). The gene discussed is FGF2; the disease is melanoma.