Although no statistically significant difference in clinical outcomes has been found in endometrial adenocarcinomas (Scobie et al, 2003), nasopharygeal carcinomas (Bar-Sela et al, 2003) and small cell carcinomas of the urinary bladder (Pan et al, 2005), two studies on ovarian cancers (Tonary et al, 2000) and neuroblastomas (Krams et al, 2004) indicated an association between a loss of the c-kit expression and poor prognosis. This evidence concerns the gene KIT and urinary bladder small cell neuroendocrine carcinoma.