In prostate cancer cell lines, the constitutive activity of Akt is mainly due to the constitutive activation of EGFR (Le Page et al, 2005) and PDGFR (Dolloff et al, 2005) in association with a loss of PTEN (Dong et al, 1998; Gray et al, 1998; Suzuki et al, 1998). The gene discussed is AKT1; the disease is prostate carcinoma.