The antiangiogenic effect observed in the ACN/IFN-γ xenografts was not mediated by the CXCL9 and CXCL10 proteins, a finding that contrasts with results from other tumour models (Strieter et al, 1995, Sgadari et al, 1996, Pertl et al, 2001) and with our previous observation that CXCL10 (IP-10) mRNA was induced in IFN-γ-transfected ACN cells (Airoldi et al, 2004). This evidence concerns the gene IFNG and neoplasm.