Human IFN-γ inhibits endothelial migration and proliferation (Brouty-Boye and Zetter, 1980; Friesel et al, 1987; Tsuruoka et al, 1988; Albini et al, 2000) and has strong antiproliferative effects on NB tumour cells (Ponzoni et al, 1992; Airoldi et al, 2004), from which the human endothelial cells derived. This evidence concerns the gene IFNG and neuroblastoma.