MYC and neoplasm: High tumour vascularity correlates with metastatic disease, MYC amplification, unfavourable histology and poor outcome; by contrast, low tumour vascularity is associated with favourable prognostic features, such as localised disease and favourable histology (Meitar et al, 1996; Canete et al, 2000; Katzenstein et al, 2000; Ribatti et al, 2002).