CXCL8 and systemic lupus erythematosus: The haplotype estimation for the -353 T/A and +781 C/T IL-8 polymorphisms revealed a strong degree of linkage disequilibrium between the two variants (D' = 0.9) and showed a slight but non-significant increase of the -353T-+781C haplotype in SLE patients (8.5% vs 6.2%, P = 0.08, OR = 1.41, 95%CI = 0.94–2.10) (Table 3).