Regarding IL-8 polymorphisms, the AT -353 genotype and the -353T/+781C haplotype showed an increased among lupus patients without nephritis compared with patients with nephritis (39.2% vs 49.4%, P = 0.03, OR = 0.66, 95%CI = 0.44–0.99 for AT -353 genotype) (5.7% vs 10%, P = 0.05, OR = 0.55, 95%CI = 0.28–1.05 for -353T/+781C haplotype) (table 4). The gene discussed is CXCL8; the disease is nephritis.