IFN-γ-mediates pancreatic beta-cell death and the subsequent development of immune-mediated diabetes [11,12] and accelerates the development of lupus-like disease and nephritis in NZW × NZB- after treatment of F1 mice, whereas antibodies to IFN-γ can block or delay the progression of the disease [13,14]. Here, IFNG is linked to type 1 diabetes mellitus.