The results show that CSF chemokine concentration of MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, RANTES/CCL5, IL-8/CXCL8 and fractalkine/CX3CL1 is positively correlated with the severity of dementia and the viral load, indicating HIV induced brain damage. This evidence concerns the gene CCL3 and dementia.