Boyko et al. followed 137 non-diabetic Japanese-American men for changes in visceral adiposity over 5 years and demonstrated that insulin resistance of the stage accompanied with high insulin level preceded increased visceral adiposity.22 Judging from these reports, it is suggested that the repetition of rapid eating would cause obesity through insulin resistance.23,24. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.