BIRC5 and breast carcinoma: Although this effect was observed in all cell types, the overall magnitude of down-regulation varied between individual cell lines; for example, whereas Raji lymphoma, T98G glioblastoma, and T47D breast carcinoma cells displayed a very strong down-regulation of survivin, LN229 glioblastoma, MCF7 breast carcinoma, and HCT116 colon carcinoma showed a weaker response at the same concentrations.