BIRC5 and neoplasm: But when the mutational status of the p53 gene in these cell lines was investigated from data of the published literature (presented at the top of Figure 2A), and was compared among cell lines of the same tumor type, it appeared that the presence of mutant p53 exerted a small, yet noticeable influence on the efficacy of survivin down-regulation by DMC and celecoxib in some of the cells.