In several tumours, overexpression of securin is associated with tumour metastasis and poor clinical outcome and has been identified as a significant prognostic marker in esophageal carcinoma (Zhang et al, 1999; Heaney et al, 2000; Shibata et al, 2002; Ramaswamy et al, 2003). Here, PTTG1 is linked to neoplasm.