The human securin (human pituitary tumour transforming gene, hPTTG1) is an oncogene with little expression in normal adult colon tissue (Zhang et al, 1999) in contrast to strong expression in colorectal cancer (Heaney et al, 2000) and other human tumours (Dominguez et al, 1998; Kakar, 1998; Shibata et al, 2002) and several carcinoma cell lines (Kakar, 1998; Zhang et al, 1999). This evidence concerns the gene PTTG1 and colorectal cancer.