In support of this hypothesis, we show that securin, like 12 well-known β-catenin/TCF target genes (e.g. c-myc, c-Met, survivin and MMP7), is significantly overexpressed in colorectal cancer compared to normal mucosa using DNA microarray analysis, real-time PCR and immunohistochemistry. The gene discussed is BIRC5; the disease is colorectal cancer.