All five genes are essential to myeloid (EHZF), megakaryocytic (FOG1 and FOG2), T-lymphoid (BCL11B) and B-lymphoid (BCL11A) development; three (BCL11A and B, EHZF) have been implicated in hematological malignancy [10,36-38]. Here, BCL11B is linked to hematologic disorder.