RET and neoplasm: Here, 17,511 of 17,922 markers observed as LOSS in tumor/normal pairs were called LOSS in unpaired tumors by the HMM (for a sensitivity of 97.7%), and 15,962 of 16,364 markers that were observed as RET in tumor/normal pairs were called RET in unpaired tumors (for a specificity of 97.5%) (Table S1A).