LYVE1 and neoplasm: LYVE-1, one of the best studied lymphatic markers is a lymph specific receptor for Hyaluronan (HA) (Banerji et al, 1999) an abundant extracellular matrix glycosylaminoglycan which facilitates cell migration in wound healing, tumour metastasis and inflammation by forming a pericellular matrix surrounding fibroblasts and epithelial cells, reducing the level of intercellular adhesion (Knudson and Knudson, 1993; Knudson et al, 1993).