Several reports, based mainly on the expression of HER1 and HER2, demonstrate that the EGF family of receptors are involved in poor prognosis in various cancers including bladder cancer (Lonn et al, 1995; Arpino et al, 2004; Blackwell et al, 2004; Popov et al, 2004). The gene discussed is ERBB2; the disease is cancer.