Whereas, 100% of tumours overexpressing HER1 or HER2 with low expression of HER3 and HER4 (+HER1/−HER3/−HER4) and (+HER2/−HER3/−HER4) correlated with late stage (T2–T4) of the bladder cancer. The gene discussed is ERBB3; the disease is urinary bladder cancer.