ERBB2 and malignant colon neoplasm: Similar results are described in the study of Nathason et al [22]; they examined HER-2/neu gene amplification in 169 colon cancer specimens and HER-2/neu protein expression in 139 specimens, where they found HER-2/neu to be overexpressed in 5 cases (3.6%) and the gene to be amplified in 4 of these cases (2.4%).