In the present study, with a group patient suffering from both CRS and allergic asthma, their CRS was treated with functional sinus endoscopic surgery (FESS), we aimed to observe: (i) amelioration of clinical symptom of asthma; (ii) regulation of Th2 response and (iii) the role of SEB in the maintenance of the skewed Th2 polarization in separated PBMCs. The gene discussed is SETBP1; the disease is congenital rubella syndrome.