Other errors may be more difficult to resolve: ANXA5 was annotated with "prostanoid biosynthesis" (GO:0046457) in a reference to a study by McGinty et al. [43] on Cyclooxygenase-2 (Cox-2) – an enzyme responsible for catalyzing the committed step in prostanoid biosynthesis – in which ANXA5 was only stained to assess the trophic withdrawal apoptosis level in pheochromocytoma cells. The gene discussed is ANXA5; the disease is hereditary pheochromocytoma-paraganglioma.