It has been suggested that, in comparison with people with diabetes who do not adhere to their treatment regimen, cognitive decline is less in people adhering to either a monotherapy (use of sulfonylurea, metformin, or thiazolidinedione) or combination (sulfonylurea with another glucose-lowering agent, insulin, or metformin and insulin) [2,43], but other research does not support this finding with people who are using short-term glycemic control.[20]. This evidence concerns the gene INS and diabetes mellitus.