Since the alteration of KIAA0101 expression reported so far was based on mRNA transcription, we studied the KIAA0101 protein expression level in human HCC as compared with the matched non-cancerous liver tissues by using an antibody prepared in our laboratory, and further investigated its subcellular localization in HCC cells and its biological effect on HCC growth and cell cycle. Here, PCLAF is linked to hepatocellular carcinoma.