Since EAS has been described in medullary thyroid carcinoma and the patient had multinodular goiter in association with hyperthyroidism, subtotal thyroidectomy was performed with the intention to exclude medullary thyroid carcinoma and resect the proven autonomous adenoma simultaneously in the face of a normal basal calcitonin and lacking pentagastrin stimulated calcitonin [8,10]. The gene discussed is CALCA; the disease is multinodular goiter.