CSF3 and pneumococcal meningitis: Not surprisingly caused an elimination of peripheral leukocytes by cyclophosphamide an attenuated pleocytosis in experimental pneumococcal meningitis [10,11], but also an altered neutrophil function with pneumococcal bacteraemia could be of importance, since a decreased chemotactic ability of neutrophils with G-CSF pretreatment [9] and a blocking of adhesion molecules [23] has been associated with an attenuated pleocytosis.