EGFR and head and neck squamous cell carcinoma: Other elements, particularly implicated in tumorigenesis and considered as prognostic factors in HNSCC may also play a role in VEGF-A regulation, such as the hypoxia-inducible factor (HIF)-1 alpha, the product of the tumour suppressor gene p53, the Epidermal Growth Factor Receptor (EGFR) or the cyclooxygenase-2 (COX-2) (Quon et al, 2001; Cohen, 2004).