FLT4 and breast cancer: More recently, a recombinant adeno-associated virus expressing a soluble VEGFR-3 was shown to inhibit lymph node metastasis in a melanoma model in mice (Lin et al, 2005) and inhibition of VEGF-C expression using small interfering RNA-mediated gene silencing reduced lymphangiogenesis, lymph node metastasis and spontaneous lung metastasis in a mouse mammary tumour model (Chen et al, 2005).