FLT4 and cancer: It is yet to be determined if a soluble VEGFR-3 construct binds VEGF-C and VEGF-D so that these growth factors are also unable to activate endogenous VEGFR-2 – if this were the case soluble VEGFR-3 would have the merit of preventing the contribution made by these growth factors to angiogenic signalling in cancer via VEGFR-2 as well as lymphangiogenic signalling via VEGFR-3.