Clinicopathological studies carried out over the past 7 years have reported that expression of VEGF-C, VEGF-D or VEGFR-3 can correlate with lymph node metastasis in human cancer, a topic that has been extensively reviewed in recent times (Stacker et al, 2002a, 2002b; He et al, 2004). This evidence concerns the gene VEGFD and cancer.