FLT4 and lung carcinoma: For example, the highly metastatic human lung cancer cell line NCI-H460-LNM35 was transfected with an expression construct for a soluble version of VEGFR-3 (soluble VEGFR-3) that binds VEGF-C and thereby inhibits signalling by endogenous VEGFR-3 (He et al, 2002).