Other protein growth factors that have also been implicated in tumour lymphangiogenesis are platelet-derived growth factors (PDGFs) (Cao et al, 2004) and VEGF-A (Hirakawa et al, 2005), however, the evidence for involvement of these molecules in tumour lymphangiogenesis is currently restricted to relatively few animal models and therefore requires analysis in a broader range of experimental models as well as extensive clinicopathological studies to correlate the expression of these molecules with metastasis in human cancer. Here, VEGFA is linked to neoplasm.