Studies performed in Ethiopia on the stimulation of PBMC from CL and diffuse cutaneous leishmaniasis, a disease clinical and pathologically distinct from DL, have shown that PBMC from CL produce more IFN-γ when stimulated with L. aethiopica antigen from CL than by antigen from diffuse cutaneous leishmaniasis. Here, IFNG is linked to diffuse cutaneous Leishmaniasis.