Breast tumours and normals were also distinguished by the expression profile of HDAC4 and CREBBP. Using ICA we alsofound a pattern of relative expression over all 12 genes (ML-IC7, see Additional file 4) that is able to discriminate tumours from normals acrossfour different tissue types (Breast, Colorectal, Renal and Bladder). This evidence concerns the gene CREBBP and neoplasm.