In pairwise comparisons with their matched normal tissue all renal tumours expressed higher levels of EZH2. Breast tumours were distinguished as a group from normal breast tissues by the expression of EZH2, CREBBP and HDAC4. Although the number of normal breast samples available was small the analysis is robust statistically and it is reassuring to see thatfor the single gene (EZH2) out of the 3 that are discriminatory and for which independent data exists the results are concordant with our findings (EZH2 is overexpressed in cancers vs normals) [24]. This evidence concerns the gene CREBBP and cancer.