HLA-DRB1 and rheumatoid arthritis: In this logistic regression, both RA associated DRB1 specificities exerted independent significant influences on the disease risk (OR 3.23, p < 0.001 for DRB1*04; OR 1.95, p < 0.001 for DRB1*01), while the 1858T allele retained its significant impact (OR 2.22, p < 0.001).