In a series of experiments, it was shown that the part of the HTR1A gene promoter that contains SNP rs6295 binds to the transcription factor named nuclear deformed epidermal autoregulatory factor DEAF-1/suppressin (NUDR), that this factor represses transcription of HTR1A and that this inhibitory action was impaired for the G-allele, the same allele that was associated with suicide and major depression [6]. The gene discussed is HTR1A; the disease is major depressive disorder.