However, nuclear localization of FABP7 may be associated with infiltrative phenotype of glioma cells and EGFR pathways based on several findings: correlation of nuclear FABP7 immunoreactivity with poor prognosis of younger patients with GBM, association with EGFR expression in GBM, lack of nuclear FABP7 immunoreactivity in grade I astrocytomas, and induction of translocation of FABP7 into nucleus in glioma cells after EGFR activation. Here, EGFR is linked to central nervous system cancer.