NG2, a chondroitin sulfate proteoglycan, is expressed by oligodendrocyte progenitors, and identification of one type of GFAP-negative/NG2-positive astrocytes in adult normal brain and a subset of gliomas led to a hypothesis that certain gliomas arise from the NG2-positive progenitor cells [34]. The gene discussed is GFAP; the disease is central nervous system cancer.