This tumour was initially described as a DLBCL with immunoblastic or large B cells and a phenotype resembling the terminally differentiated B cell, characterized by negative or weak expression of mature B-cell markers (CD20) and positivity for plasma cell-associated antigens (CD38, CD138).63 The tumours were mainly diagnosed in patients infected with the human immunodeficiency virus (HIV) and they presented commonly in the mucosa of the oral cavity. Here, CD38 is linked to neoplasm.