ALK and anaplastic large cell lymphoma: A recent paper using FISH for the 2p23 locus showed extra copies of chromosome 2p23 in all five samples from four patients with ALK– anaplastic large-cell lymphoma and in five of seven primary cutaneous anaplastic large-cell lymphomas, but in none of six ALK+ anaplastic large-cell lymphomas.140 Zettl et al. found imbalances in chromosome 2 in five (26%) of nodal/systemic anaplastic large-cell lymphomas (one ALK+, four ALK–) and no primary cutaneous anaplastic large-cell lymphoma.