ALK+ primary CNS anaplastic large-cell lymphomas (approximately 50%) have been reported to have a better prognosis.132 An unusual feature of primary CNS anaplastic large-cell lymphoma is the high degree of involvement of the dura or leptomeninges (69%).131,132 A CD56+, ALK+, t(2;5)(p23;q35)+, primary brain anaplastic large-cell lymphoma in a 27-year-old immunocompetent male was included in the Workshop (Figure 8). This evidence concerns the gene ALK and anaplastic large cell lymphoma.