The second ALK– anaplastic large-cell lymphoma expressed CD15 and CD30 and the differential diagnosis was Hodgkin's lymphoma versus a CD15+ anaplastic large-cell lymphoma versus a CD15+, CD30+ peripheral T-cell lymphoma.135,136 Whether CD15 expression excludes a diagnosis of anaplastic large-cell lymphoma and whether CD15+, CD30+ T-cell lymphomas represent a specific entity will be answered when more cases have been studied. This evidence concerns the gene ALK and anaplastic large cell lymphoma.