However, to make a diagnosis of ALK– anaplastic large-cell lymphoma there must be strict adherence to characteristic cytology (a large cell predominant population with abundant cytoplasm and pleomorphic, embryo or hallmark nuclei or wreath-like giant cells) and strong CD30 expression with a membrane and Golgi distribution in virtually every cell. The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.