Angele et al (2003) report that of the three major ATM haplotypes, one was significantly associated with breast cancer risk in French women. Similar results were also reported from Korea (Lee et al, 2005). Conversely, Tamimi et al (2004) used a large collection of cases and controls (more than 1300 individuals in each group) from the Nurses Health study, and report that none of five common ATM haplotypes was associated with breast cancer risk in American women. This evidence concerns the gene ATM and breast cancer.