We first tested the panel of commonly used pancreatic cancer cell lines shown in Table 1, which covers all tumour grades and genetic mutations, and includes cell lines derived from primary tumours, ascites, and liver and lymph node metastases, in serum-free adhesion assays on the stromal ECM proteins, type I collagen, fibronectin, and vitronectin, and the basement membrane proteins, type IV collagen and laminin. The gene discussed is LAMB2; the disease is familial pancreatic carcinoma.