TP53 and Wilms tumor: Besides these two genes, many other mutational events, such as allelic loss of chromosome 16q (Maw et al, 1992), loss of heterozygosity at 11q23.3-q-ter region (Radice et al, 1995), and high rate of P53 mutations located at 17p13 (Bardeesy et al, 1994) in Wilms tumour indicate the involvement of these genes/loci with Wilms tumour formation.