Interestingly, human glioblastoma cells, such as A172, U87MG and U373MG, display differential responsiveness to TRAIL-related cytotoxicity in vitro and in vivo (Pollack et al, 2001; Nabors et al, 2003; Kasuga et al, 2004), and also release substantial amounts of VEGF in response to hypoxia (Acker and Plate, 2004). The gene discussed is TNFSF10; the disease is glioblastoma.