To do so, we verified the hypothesis whether TRAIL could influence angiogenesis-related genes in both the three human glioblastoma cell lines A172, U87MG and U373MG, as well as in human umbilical vein endothelial cells (HUVECs), by means of a specific microarray (Zheng et al, 2000). This evidence concerns the gene TNFSF10 and glioblastoma.