Moreover, such a high angiogenic potential of glioblastoma appears associated with high expression of tissue remodelling-related molecules, such as the matrix metalloproteinase-2 (MMP-2) and its inhibitor, named tissue inhibitor of metalloproteinases-2 (TIMP-2), both concurring, along with angiogenesis, to tumour growth (Fillmore et al, 2001; VanMeter et al, 2001). The gene discussed is TIMP2; the disease is glioblastoma.