MKI67 and dysplasia: There was a positive correlation between Mcm-2 LI and Ki67 LI values in the superficial epithelial third for all samples combined (Spearman's ρ=0.85, P<0.0001) (Figure 3), with the Mcm-2 LI being significantly greater than the Ki67 LI in the superficial epithelial third in severe (P=0.001), moderate (P=0.001) and mild dysplasia (P=0.004, Wilcoxon signed rank test) (Figure 2).