TNF and rheumatoid arthritis: After adjustment for being older than 60 years (HR = 1.51 [95% CI, 1.37–1.67]), having a disease duration longer than three years prior to therapy with TNF antagonist (HR = 1.29 [95% CI, 1.12–1.48]), and using infliximab (HR = 2.52 [95% CI, 2.11–2.99]), the HR for an AE in SpA versus RA was 0.80 [95% CI, 0.70–0.91].