GSTM1 and obesity due to melanocortin 4 receptor deficiency: Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.