To explore further the role played by potentially functional VEGF polymorphisms, we examined the association between the three promoter region polymorphisms (-2578C/A, -1154G/A and -634G/C) and a 3'-untranslated region polymorphism (+936C/T) and risk for incident breast cancer using postmenopausal cases and controls from the CPS-II (Cancer Prevention Study II) Nutrition Cohort. Here, VEGFA is linked to breast cancer.