For example, The Global Utilization of Streptokinase and tPA for Occluded coronary arteries (GUSTO) study, published in 1993, found a statistically and clinically significant decrease in mortality for acute myocardial infarction in patients who were treated with accelerated tPA compared to those treated with streptokinase ($33,000 per life-year saved) and traditional subgroup analyses did not accurately identify subgroups that did not benefit[24]. Here, PLAT is linked to myocardial infarction.