In a recent study using proteomic technology to identify a protein of human dermal microvascular endothelial cells that reacts with anti-endothelial cell antibodies of patients with BD, Lee and colleagues [2] identified α-enolase, another ubiquitous protein, as an autoantigen recognized by serum IgM from patients with BD, thus confirming the importance of anti-endothelium IgM in BD. Here, CD40LG is linked to Behcet disease.