HPSE and thrombotic disease: Thus, it has been reported that polymorphism of HPA is a genetic risk factor for thrombotic diseases (Weiss et al., 1996; Gonzalez-Conejero et al., 1998; Sperr et al., 1998; Carter et al., 1999; Kroll et al., 2000; Baker et al., 2001; Mikkelsson et al., 2001, 2002; Jilma-Stohlawetz et al., 2003).