RNASEL and hereditary chronic pancreatitis: Several germline mutations or variants in HPC1/RNASEL have been observed in HPC [10–13] (reviewed in [16]), including a common (35% allelic frequency) missense variant of RNase L, in which a G to A transition at nucleotide (nt) position 1385 (G1385A) results in a glutamine instead of arginine at amino acid position 462 (R462Q).