While Boucharaba and colleagues did not specifically investigate the role of tumor αvβ3, they showed that interaction of human MDA-MB-231/B02 breast tumor cells with platelets promotes osteoclast-mediated bone resorption through the release of cytokines (IL-6 and IL-8) in response to platelet-derived lysophosphatidic acid. The gene discussed is CXCL8; the disease is breast neoplasm.