In this study we are investigating prospectively the role of Chlamydia pneumoniae, chlamydial heat shock protein 60 and a possible intermediate role of human heat shock protein 60 sero-status in the development of secondary CVD events in patients with coronary heart disease (CHD) under special consideration of diabetes, also comparing the relationship between chlamydial sero-markers of infection, heat shock proteins and secondary cardiovascular disease (CVD) events in patients with diabetes with those without. This evidence concerns the gene HSPD1 and coronary artery disorder.