Others appear to be involved in epidermal differentiation and proliferation (KRT15, IGF1, PGR and HPN), cell growth and development (FGFR2), apoptosis (DBCCR1 and CLU), lipid metabolism (AMACR), etc. Very significantly, multiple isoforms from AMACR, a key player in catalyzing the isomerization of alpha-methyl-branched fatty acid and a recently reported good prostate cancer marker, show the strongest signal in our data [46]. The gene discussed is CLU; the disease is prostate carcinoma.