APC and retinoblastoma: It was believed that mutation or amplification of oncogenes c-ras, c-erbB-2, K-sam, c-met, and c-myc and inactivation of tumor suppressor genes p53, adenomatosis polyposis coli (APC), deleted in colorectal carcinomas (DCC), and retinoblastoma (RBI) are related to the development of gastric cancer.