TLR2 and chronic obstructive pulmonary disease: However, monocytes from smokers expressed significantly less TLR-2 than monocytes from AECOPD patients (3.40 ± 0.5 mfi vs 6.78 ± 2.09 mfi, respectively, p = 0.001) and monocytes from COPD patients (3.40 ± 0.5 mfi vs 6.02 ± 2.09 mfi, respectively, p = 0.02).