We found that the plasma concentration of IL-6 was significantly higher in sera from AECOPD patients (5.19 ± 1.03 pg/ml) and stable COPD patients (5.75 ± 0.86 pg/ml) than in never smokers (2.61 ± 0.13 pg/ml, p = 0.02). This evidence concerns the gene IL6 and chronic obstructive pulmonary disease.