DNASE1 and glomerulonephritis: Mild glomerulonephritis was observed in all serum amyloid P component-deficient cohorts, with no protection provided by the over-expression of DNase I. As significantly lower levels of anti-ssDNA antibodies were observed in the ash.DNase I transgenic mice, one could conclude that in our experimental model these autoantibodies were not critical in the early stages of the renal disease.